The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed
نویسندگان
چکیده
منابع مشابه
Engrailed Homeoprotein Protects Mesencephalic Dopaminergic Neurons from Oxidative Stress
Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected to wild-type neurons. These changes include DNA strand breaks and the modific...
متن کاملNurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons.
Nurr1 is a member of the nuclear receptor superfamily of transcription factors that is expressed predominantly in the central nervous system, including developing and mature dopaminergic neurons. Recent studies have demonstrated that Nurr1 is essential for the induction of phenotypic markers of ventral mid-brain dopaminergic neurons whose generation is specified by the floor plate-derived morph...
متن کاملFate of midbrain dopaminergic neurons controlled by the engrailed genes.
Deficiencies in neurotransmitter-specific cell groups in the midbrain result in prominent neural disorders, including Parkinson's disease, which is caused by the loss of dopaminergic neurons of the substantia nigra. We have investigated in mice the role of the engrailed homeodomain transcription factors, En-1 and En-2, in controlling the developmental fate of midbrain dopaminergic neurons. En-1...
متن کاملEngrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons.
The neuropathological hallmark of Parkinson's disease is the loss of dopaminergic neurons in the substantia nigra pars compacta, presumably mediated by apoptosis. The homeobox transcription factors engrailed 1 and engrailed 2 are expressed by this neuronal population from early in development to adulthood. Despite a large mid-hindbrain deletion in double mutants null for both genes, mesencephal...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2014
ISSN: 1423-0127
DOI: 10.1186/1423-0127-21-27